この項目では、鎮咳去痰薬について説明しています。ロックバンドについては「コデイン (バンド)」をご覧ください。
Narcotic analgesics may well bring about nausea and vomiting by stimulating the chemoreceptor induce zone (CTZ); having said that, In addition they depress the vomiting Centre, to make sure that subsequent doses are unlikely to generate vomiting. Nausea is small right after common oral doses of codeine.
These persons change codeine into its Energetic metabolite, morphine, far more promptly and totally than Others. This speedy conversion-leads to increased than predicted serum morphine amounts. Even at labeled dosage regimens, people who are ultra-rapid metabolizers could possibly have life-threatening or fatal respiratory despair or working experience signs of overdose (for example extreme sleepiness, confusion, or shallow breathing). (See OVERDOSAGE). Youngsters with obstructive snooze apnea who're dealt with with codeine for article-tonsillectomy and/or adenoidectomy suffering might be specifically sensitive for the respiratory depressant effects of codeine that's been rapidly metabolized to morphine. Codeine is contraindicated for put up-operative suffering administration in all pediatric patients undergoing tonsillectomy and/or adenoidectomy. (See CONTRAINDICATIONS). When prescribing codeine-containing prescription drugs, Health care vendors should really choose the lowest helpful dose for that shortest length of time and tell patients and caregivers about these threats plus the indications of morphine overdose.
Promethazine hydrochloride takes place for a white to faint yellow, virtually odorless, crystalline powder which bit by bit oxidizes and turns blue on prolonged publicity to air.
If you are taking promethazine/phenylephrine/codeine on a regular basis all through pregnancy, your infant could possibly have withdrawal indicators that could be everyday living-threatening. Convey to your Health care company when you took promethazine/phenylephrine/codeine during your pregnancy, Primarily close to the close of one's pregnancy.
オーストラリアとカナダでは、コデインは規制されているが、許可された薬剤師による最大15mg/錠での調合による入手が処方箋なしで可能である。
Should your kidney or liver perform is impaired, your physician may well make a decision that codeine is not suitable for you. You will discover other components that may Restrict your use of codeine — for instance, in the event you drink alcohol or consider other medicines that can cause drowsiness.
Sedating medicine could induce confusion and above-sedation during the elderly; aged patients usually need to be started on reduced doses of Promethazine Hydrochloride and Codeine Phosphate Syrup and noticed closely.
Signs generally show up through the initial several days of daily life. Promethazine administered to some pregnant woman within two weeks of shipping may inhibit platelet aggregation in the newborn.
Promethazine/phenylephrine/codeine could also be utilized for other ailments as based on your healthcare company.
Codeine can be a weak narcotic pain reliever and cough suppressant that is similar to morphine and hydrocodone. A little quantity of ingested codeine is converted to morphine in the body.
In An additional study click here only one a hundred-mg/ kg dose of codeine administered to pregnant mice reportedly resulted in delayed ossification within the offspring. There isn't any scientific tests in humans, and the importance of such results to individuals, if any, will not be recognized.
Codeine has lots of unsafe results on your body and brain when taken frequently around a lot of times, weeks, and months.
Like all opioids, codeine could cause Bodily dependence. In order to avoid signs or symptoms of withdrawal, individuals who use codeine for a long period could experience the need to use it every day.